ChloroquineV1, Main, Exploration, bibRecord, 003393

Effect of twenty-three chemotherapeutic agents on the adherence and growth of Giardia lambiia in vitro

Identifieur interne : 003393 ( Main/Exploration ); précédent : 003392; suivant : 003394

Effect of twenty-three chemotherapeutic agents on the adherence and growth of Giardia lambiia in vitro

Auteurs : A. A. Crouch ; W. K. Seow ; Y. H. Thong

Source :

Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1986.

RBID : ISTEX:9EFF7308E1C2A0AD853CAFCBB548171BB9AAA6F2

English descriptors

Teeft :
- Adherence inhibition assay, Anaerobic bacteria, Antimalarial, Assay, Basal medium, Boreham, Chemotherapeutic, Chemotherapeutic agents, Comparative study, Doxycycline, Furazolidone, General microbiology, Giardia, Giardia lamblia, Giardiasis, Gillin diamond, Growth inhibition, Growth inhibition assay, Inhibition, Lamblia, Mater hospital, Mefloquine, Metronidazole, More inhibition, Nylon fibre microcolumns, Royal society, Significant insights, Suction pressure, Tetracycline, Tinidazole, Trophozoite, Tropical medicine.

Abstract

Abstract: The sensitivity of Giardia lamblia to 23 chemotherapeutic agents was evaluated in vitro with a Growth Inhibition Assay and a recently developed Adherence Inhibition Assay. Of the four established anti-giardia drugs, tinidazole, metronidazole, and furazolidone were found to have strong inhibitory effects on both growth and adherence, while mepacrine had a strong effect on growth only. Three drugs (mefloquine, doxycycline and rifampin) not previously used in giardiasis were found to have significant activity in vitro and may deserve consideration for clinical evaluation of efficacy. Also, the concurrent use of these two in vitro methods provided significant insights into the modes of action of some of these drugs on G. lamblia.

Url:

DOI: 10.1016/0035-9203(86)90249-X

Affiliations:

Le document en format XML

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Effect of twenty-three chemotherapeutic agents on the adherence and growth of Giardia lambiia in vitro

Effect of twenty-three chemotherapeutic agents on the adherence and growth of Giardia lambiia in vitro

Source :

English descriptors

Abstract

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Le document en format XML

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